Rapid Progressivity in a 62-Year-Old Circumcised Man with Penile Cancer: A Case Report

Patricia Prabawati, Farid Setyono

Abstract

Penile cancer is a rare malignancy globally, including in Indonesia, with notable morbidity and mortality rates. This case report discusses a 62-year-old male with a penile mass, emphasizing the diagnostic challenges and the importance of early intervention in penile cancer cases. The patient presented with a progressively growing penile mass, dysuria, and penile pain. Clinical examination revealed a palpable, reddish mass on the penile shaft with unclear borders, a urethral fistula, and enlarged inguinal lymph nodes. Laboratory results showed white blood cell count, haemoglobin, platelet count, glucose, blood urea nitrogen, and creatinine abnormalities. An open biopsy suggested verrucous carcinoma, later revised to penile squamous cell carcinoma with inguinal lymph node metastases. Penile cancer, particularly squamous cell carcinoma, primarily affects older, uncircumcised men. Verrucous carcinoma, though rare, is associated with poor hygiene and lack of circumcision. Notably, misdiagnoses may occur due to the limited scope of open biopsies. Penile cancer is preventable, and its significant risk factors are modifiable. Penile carcinoma, although uncommon, poses severe consequences for affected individuals. Early diagnosis and intervention are crucial for improved outcomes. This case highlights the challenges in diagnosis, emphasizing the need for comprehensive assessments and awareness of the modifiable risk factors associated with penile cancer.

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References

Ahmed, M. E., Khalil, M. I., Kamel, M. H., Karnes, R. J., & Spiess, P. E. (2021). Progress on management of penile cancer in 2020. Current Treatment Options in Oncology, 22, 1–13.
Borque-Fernando, Á., Gaya, J. M., Esteban-Escaño, L. M., Gómez-Rivas, J., García-Baquero, R., Agreda-Castañeda, F., Gallioli, A., Verri, P., Ortiz-Vico, F. J., & Amir-Nicolau, B. F. (2023). Epidemiology, Diagnosis and Management of Penile Cancer: Results from the Spanish National Registry of Penile Cancer. Cancers, 15(3), 616.
Brouwer, O. R., Albersen, M., Parnham, A., Protzel, C., Pettaway, C. A., Ayres, B., Antunes-Lopes, T., Barreto, L., Campi, R., & Crook, J. (2023). European association of urology-american society of clinical oncology collaborative guideline on penile cancer: 2023 update. European Urology.
Burnett, A. L. (2016). Penile preserving and reconstructive surgery in the management of penile cancer. Nature Reviews Urology, 13(5), 249–257.
Deo, A., Borkar, M., Sagrule, D., Gadade, G., & Borse, S. (2023). Rare presentation of penile cancer: a case report. International Surgery Journal, 10(3), 509–511.
Douglawi, A., & Masterson, T. A. (2017). Updates on the epidemiology and risk factors for penile cancer. Translational Andrology and Urology, 6(5), 785.
Ferlay, J., Ervik, M., Lam, F., Colombet, M., Mery, L., & Piñeros, M. (2020). The Global Cancer Observatory-All cancers. International Agent for Research on Cancer-WHO, 419, 199–200.
Hadidi, A. T. (2022). Surgical Anatomy of the Penis and Urethra. In Hypospadias Surgery: An Illustrated Textbook (pp. 105–126). Springer.
Hakenberg, O. W., Dräger, D. L., Erbersdobler, A., Naumann, C. M., Jünemann, K.-P., & Protzel, C. (2018). The diagnosis and treatment of penile cancer. Deutsches Ärzteblatt International, 115(39), 646.
Lestari, D. P. O., & Armerinayanti, N. W. (2018). Increasing trend of penile cancer cases in Bali compared to other regions in Indonesia. IOP Conference Series: Materials Science and Engineering, 434(1), 12156.
Morrison, J. (2015). When psychological problems mask medical disorders: A guide for psychotherapists. Guilford Publications.
Rizwan, A., Bulte, C., Kalaichelvan, A., Cheng, M., Krishnamachary, B., Bhujwalla, Z. M., Jiang, L., & Glunde, K. (2015). Metastatic breast cancer cells in lymph nodes increase nodal collagen density. Scientific Reports, 5(1), 10002.
Thomas, A., Necchi, A., Muneer, A., Tobias-Machado, M., Tran, A. T. H., Van Rompuy, A.-S., Spiess, P. E., & Albersen, M. (2021). Penile cancer. Nature Reviews Disease Primers, 7(1), 11.
Wang, W., Jiao, Y., Zhang, L., Fu, C., Zhu, X., Wang, Q., & Gu, Y. (2022). Multiparametric MRI-based radiomics analysis: differentiation of subtypes of cervical cancer in the early stage. Acta Radiologica, 63(6), 847–856.
White, J., Mason, R., Lawen, T., Spooner, J., Faria, K. V. M., Rahman, F., & Ramasamy, R. (2023). Therapeutic Approaches to Penile Cancer: Standards of Care and Recent Developments. Research and Reports in Urology, 165–174.

Authors

Patricia Prabawati
[email protected] (Primary Contact)
Farid Setyono

Article Details