Pansitopenia as a Marker of Advanced Human Immunodeficiency Virus (HIV) infection: How Often? A Case Study Accompanied by Literature

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Muhammad Hikmawan Priyanto
General Hospital Kabupaten Batang
Muhammad Faizun
General Hospital Kabupaten Batang

Pansitopenia is a condition characterized by anemia, thrombocytopenia, and leukopenia. One of the common etiologies of Pansitopenia is HIV infection. In advanced HIV, Pansitopenia may present even without other clinical findings leading to a diagnosis of HIV. This study was conducted as a case study of a 34-year-old man who presented with chief complaints of chronic diarrhea and fever that lasted for one month. Laboratory examination showed Pansitopenia, HIV-rapid reactive and peripheral blood picture indicating Pansitopenia/ aplastic anemia. Data were collected through history taking, physical examination, and a series of laboratory tests. The patient was diagnosed with Pansitopenia suspected to be caused by HIV infection. The chief complaints of chronic diarrhea and fever suggested a chronic disease process due to immune compromise, as seen in the patient's clinical status indicating advanced HIV. The literature suggests that the severity of pansitopenia depends on the severity of HIV disease. Pansitopenia can be an indicator of the advanced stage of HIV infection. Appropriate management and regular monitoring are essential to prevent further complications. Pansitopenia in HIV patients can be considered as an important indicator to assess the severity of the infection. Prompt treatment and antiretroviral therapy are highly recommended to improve the prognosis of patients.


Keywords: chronic diarrhea, pansitopenia, aplastic anemia, Human Immunodeficiency Virus (HIV)
Aresta, A. S., & Jumaiyah, W. (2019). Pengetahuan Dan Dukungan Keluarga Dengan Kepatuhan Dalam Menjalankan Pengobatan Antiretroviral (ARV) Pada Pasien HIV/AIDS. Indonesian Journal of Nursing Sciences and Practice, 2(2), 51–61.
Arifin, B., Rokhman, M. R., Zulkarnain, Z., Perwitasari, D. A., Mangau, M., Rauf, S., Noor, R., Padmawati, R. S., Massi, M. N., & Schans, J. van der. (2023). The knowledge mapping of HIV/AIDS in Indonesians living on six major islands using the Indonesian version of the HIV-KQ-18 instrument. PLoS One, 18(11), e0293876.
Armstrong, W. S., Guarner, J., Kraft, C. S., & Caliendo, A. M. (2016). Human immunodeficiency virus. Diagnostic Microbiology of the Immunocompromised Host, 51–68.
Blood, G. A. C. (2016). Human immunodeficiency virus (HIV). Transfusion Medicine and Hemotherapy, 43(3), 203.
Bukhori, B., Hidayanti, E., & Situmorang, D. D. B. (2022). Religious coping strategies for people with HIV/AIDS (PLWHA) Muslims in Indonesia: A qualitative study with a telling-the-stories. Heliyon, 8(12).
Chew, S., & Kamangar, M. (2024). Approach to pancytopenia: From blood tests to the bedside. Clinical Medicine, 100235. https://doi.org/10.1016/j.clinme.2024.100235
De Torres, R. Q., Pacquaio, D. F., Ngaya-an, F. V, & Tuazon, J. A. (2021). Adherence to Antiretroviral Therapy and Scheduled Clinic Visits of Persons Living with HIV in the Philippines. J of Nurs Practice and Rev of Research, 11(2), 19–30.
Harini, R., & Susanti, H. (2017). Peer Counselor Training on Knowledge, Attitudes and Skills of Central Committee of Student Health Information and Reproductive Health Consultation (PIK-KRM). Health Science International Conference (HSIC 2017), 28–40.
Hossain, F., Hasan, M., Begum, N., Mohan, D., Verghis, S., & Jahan, N. K. (2022). Exploring the barriers to the antiretroviral therapy adherence among people living with HIV in Bangladesh: A qualitative approach. Plos One, 17(10), e0276575. https://doi.org/10.1371/journal.pone.0276575
Isni, K., & Matahari, R. (2018). The role of Wijaya Kusuma’s Youth Information and Counseling Center (PIK-R) on adolescent health problems. International Journal of Public Health Science (IJPHS), 7(1), 27–32.
MD, L. R. (2021). Comorbidities And Adverse Drug Effects In People Living with HIV In A Modern Treatment Era: Risk Factors and Prognosis.
Montejano, R., de Miguel, R., & Bernardino, J. I. (2019). Older HIV-infected adults: complex patients—comorbidity (I). European Geriatric Medicine, 10(2), 189–197.
Priyanto, M. H., & Mas’ud, I. (2024). Pansitopenia: Challenges Of Approach And Case Handling In Peripheral Hospitals. Eduvest-Journal of Universal Studies, 4(10), 9565–9584. https://doi.org/10.59188/eduvest.v4i10.43691
Pudjiati, A. S. R., Imtihani, H., Luthfiandi, M. R., & Susetiati, D. A. (2019). Association between sexual orientation and sexual contact with the incidence of human immunodeficiency virus (HIV) infection in Dr. Sardjito General Hospital, Yogyakarta. Journal of the Medical Sciences, 51(1), 36–43.
Santiago-Rodríguez, E. J., Mayor, A. M., Fernández-Santos, D. M., & Hunter-Mellado, R. F. (2016). Profile of HIV-infected hispanics with pancytopenia. International Journal of Environmental Research and Public Health, 13(1), 38. https://doi.org/10.3390/ijerph13010038.
Shalini C, O. D. (2023). Pansitopenia. StatPearls Publishing.
Surahmawati, S., & Faisal, A. A. A. (2023). Relationship Of Use Of Youth Information And Counseling Center (PIK-R) Services On Adolescent Reproductive Health Behavior At SMAN 2 Gowa. Homes Journal: Hospital Management Studies Journal, 4(1), 19–29.