The Use of Natural Ingredients as Topical Therapy for the Treatment of Second-Degree Burns: A Review Article

Authors

  • Ni Nyoman Ita Trisnadewi Universitas Udayana
  • Desak Ketut Ernawati Universitas Udayana
  • Agung Nova Mahendra Universitas Udayana

DOI:

https://doi.org/10.58344/ihj.v5i2.890

Keywords:

second degree burns, natural ingredients, topical therapy, phytochemical compounds

Abstract

Second-degree burns are skin tissue damage involving the epidermis and part of the dermis, requiring appropriate treatment to prevent infection and accelerate tissue regeneration. Conventional therapy remains the primary choice, but long-term use can cause certain side effects. This situation has encouraged the increasing use of natural ingredients as alternative therapies because they are considered safer, easier to obtain, and contain bioactive compounds that support the wound healing process. This review article aims to assess the potential of various natural ingredients as topical therapies for healing second-degree burns. The method used is a literature review of research articles published between 2021 and 2026 through Google Scholar, PubMed, ScienceDirect, and DOAJ. The results of this study indicate that various plants such as kepok banana, moringa, breadfruit, red dragon fruit, and other herbal plants are effective in the burn healing process through various dosage forms such as creams, gels, ointments, spray gels, and nanogels. The dominant phytochemical compounds found include flavonoids, saponins, tannins, alkaloids, and terpenoids, which act as anti-inflammatory, antibacterial, and antioxidant agents. Overall, natural ingredients have the potential to be developed as an alternative treatment for second-degree burns that is effective and easily accessible to the public.

References

Aisyah, C., & Asparini, R. R. (2023). The Effect Of Red Dragon Fruit Peel Extract Gel On Rattus Norvegicus Strain Wistar Of Grade Iia Burns Surface Area. APISIO Medica, 1(1), 11–17.

Astuti, D. P., & Fadhilaha, A. (2025). Effectiveness of Healing Second Degree Burns Gel Preparation of bilimbi Extract (Averroa bilimbi L.) Against Male Wistar Rats. Journal of Pharmaceutical and Sciences, 2025(2), 903–912. https://doi.org/10.36490/JOURNAL-JPS.COM.V8I2.847

Fitria, F., & Astryna, S. (2025). Aktivitas Antiinflamasi Nanogel Ekstraks Etanol Daun Sukun Pada Tikus Putih Jantan Yang Mengalami Luka Bakar Derajat II. Jurnal.Uui.Ac.IdF Fitria, SY Astryna, S SamaniyahJOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE, 2025•jurnal.Uui.Ac.Id, 11(1), 2615–109.

Harahap, M. S., Jayanti, N., & Gunawan, B. S. (2026). Formulation and Evaluation of a Pandanus amaryllifolius Leaf Ethanol Extract Ointment for Burn Wound Healing in Male Rats. JURNAL FARMASIMED (JFM), 8(2), 1203–1213. https://doi.org/10.35451/A2NWPP71

Hariningsih, Y., & Hartono, A. (2022). Formulasi Krim Ekstrak Etanol Kulit Pisang Kepok (Musa Paradisiaca Formatypica) Sebagai Penyembuh Luka Bakar. Pengembangan Ilmu Dan Praktik Kesehatan, 1(2), 48–56. https://doi.org/10.56586/pipk.v1i2.213

Hutagalung, M., Lubis, U., & Klorida, L. (2022). Pengujian Efektivitas Penyembuhan Luka Bakar Gel Ekstrak Etanol Daun Tembakau (Nicotiana tabacum L.) Pada Tikus. Scholar.Archive.OrgM HutagalungJurnal Penelitian Farmasi Dan Herbal, 2022•scholar.Archive.Org, 4, 2021–2022.

Irwandi, I., Nessa, N., & Iisranu, A. (2021). Uji Aktivitas Ekstrak Etanol Biji Buah Durian (Durio Zibethinus L.) terhadap Penyembuhan Luka Bakar pada Mencit Putih Jantan (Mus Musculus). Prosiding Seminar Kesehatan Perintis, 4(2), 152–158.

Luh Ayu Surya Dianti, N., Aisyah, R., & Hardiana, I. (2025). Efektivitas Sediaan Krim Ekstrak Daun Mangga Madu (Mangifera Indical.) Terhadap Penyembuhan Luka Bakar Derajat II Pada Tikus. Jks.Stikesbuleleng.Ac.Id, Volume 2,.

Muhaira, W. T., Luthvia, Wahyuni, N., Simatupang, I. A., & Ariatama, B. (2024). Uji Ekstrak N-Heksan Daun Kirinyuh (Chromolaena Odorata L.) Terhadap Model Hewan Luka Bakar Derajat IIA. Researchgate.NetWT Muhaira, L Luthvia, N Wahyuni, IA Simatupang, B AriatamaJurnal Riset Ilmu Kesehatan Umum Dan Farmasi (JRIKUF), 2024•researchgate.Net, Volume 2 N. https://doi.org/https://doi.org/10.57213/jrikuf.v2i4.514

Mundriyastutik, Y., Muslimah, A. C., Hasriyani, H., & Lestari, D. T. (2023). Penyembuhan Luka Bakar Dengan Sediaan Topikal Spray Gel Ekstrak Daun Peletakan (Ruellia Tuberosa L) Pada Tikus Putih (Wistar). IJF (Indonesia Jurnal Farmasi), 8(2), 84–92. https://doi.org/10.26751/IJF.V8I2.2230

Nofita, N., Salza Fadilla, S., Pratiwi, I. A., Ayu, G., Saputri, R., & Hermawan, D. (2025). Efektivitas Sediaan Gel Ekstrak Kulit Pisang Ambon (Musa paradisiaca var sapientum) Terhadap Penyembuhan Luka Bakar dan Luka Sayat. Jurnal Mandala Pharmacon Indonesia, 11(1), 308–317. https://doi.org/10.35311/JMPI.V11I1.815

Pratama, K. A. K., Putra, A. P., & Puspaningrat, D. (2023). Formulasi Krim Ekstrak Daun Kelor (Moringa Oleifera Lam) Sebagai Penyembuhan Luka Bakar Pada Tikus Putih Jantan (Rattus Norvegicus). JURNAL FARMASI KRYONAUT, 2(2), 85–96. https://doi.org/10.59969/JFK.V2I2.55

Putra, I. M. A. S., Trias, N. K. P., & Kusuma, I. G. A. W. (2026). Uji Efektivitas Salep Ekstrak Etanol Daun Buni (Antidesma bunius (L.) Spreng) Sebagai Penyembuhan Luka Bakar Grade II (A) Pada Mencit. Usadha, 5(1), 25–34. https://doi.org/10.36733/USADHA.V5I1.13940

Simorangkir, D., Puspita, R., Umaya, C., & Rimta, B. (2025). Formulasi Sediaan Gel Ekstrak Etanol Daun Bidara (Ziziphus Mauritiana L) Sebagai Penyembuhan Luka Bakar Terhadap Tikus Putih Jantan. Jurnal Penelitian Farmasi Dan Herbal, 7(2), 105–111. https://doi.org/10.36656/JPFH.V7I2.2266

Sulaiman, A. A., Maslachah, L., Utama, S., Yuniarti, W. M., Sukmanadi, M., & Hidajati, N. (2025). The Effectiveness of melinjo leaf (Gnetum gnemon L.) extract cream on the number of fibroblast cells in the second degree burn (deep partial thickness) of white rats (Rattus norvegicus). Journal of Pharmaceutical and Sciences, 2025(1), 216–223. https://doi.org/10.36490/JOURNAL-JPS.COM.V8I1.693

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Published

2026-06-14