The Relationship Between Glycosylated Hemoglobin (HbA1c) Levels and Serum Glutamic-Pyruvic Transaminase (SGPT) Enzyme Activity in Patients with Type 2 Diabetes Mellitus at The Pakuan Baru Community Health Center in Jambi City

Agraini Agraini; Ella  Putri; Fardiah  Tilawati Sitanggang

doi:10.58344/ihj.v5i3.913

Authors

Agraini Agraini Politeknik Kesehatan Kemenkes Jambi
Ella Putri Politeknik Kesehatan Kemenkes Jambi
Fardiah Tilawati Sitanggang Politeknik Kesehatan Kemenkes Jambi

DOI:

https://doi.org/10.58344/ihj.v5i3.913

Keywords:

ALT Enzyme Activity, HbA1c Value, Duration of Suffering

Abstract

Type 2 diabetes mellitus is characterized by persistent hyperglycemia that may contribute to metabolic disturbances and liver injury. Glycated hemoglobin (HbA1c) reflects average blood glucose control over approximately three months, whereas serum glutamic-pyruvic transaminase (SGPT), also known as alanine aminotransferase (ALT), is commonly used to assess hepatocellular injury. This study aimed to determine the relationship between HbA1c levels and SGPT enzyme activity in patients with type 2 diabetes mellitus at Pakuan Baru Community Health Center, Jambi City. An observational correlational design was applied to 35 adult patients selected according to predetermined inclusion and exclusion criteria. HbA1c levels were measured using an Afinion AS100 analyzer, while SGPT activity was assessed using a DIALAB automated analyzer. Because the data were not normally distributed, the relationship between variables was examined using Spearman’s rank correlation test. The participants had a median HbA1c level of 6.80%, with values ranging from 4.4% to 15.0%, and a median SGPT activity of 17.00 U/L, with values ranging from 7 to 47 U/L. The analysis showed a very weak positive correlation that was not statistically significant (r = 0.054; p = 0.759). Therefore, HbA1c levels were not significantly associated with SGPT enzyme activity in the studied patients with type 2 diabetes mellitus.

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